Ocean-sourced substance shows potential for soothing skin inflammation

Researchers from the Marine Biomedical Science and Technology Innovation Platform of Lin-Gang Special Area, collaborating with the International Combined Research Center for Marine Biological Sciences, have developed and assessed a marine-derived molecule called COS-diDA. This molecule is created by chemically bonding dopamine to β-chitooligosaccharides (COS) sourced from Sargassum, a type of brown seaweed.

COS-diDA is essentially “chitooligosaccharide-di-dopamine amide,” resulting from bonding two dopamine molecules to COS, which are derived from chitosan in crustacean shells. However, using Sargassum reduces allergen risks compared to traditional shellfish sources. Researchers synthesized COS-diDA under mild alkaline conditions and verified it using ultraviolet spectroscopy, infrared analysis, and mass spectrometry. The addition of dopamine enhances COS’s bioactivity, making it more effective in reducing inflammation and adhering to skin cells.

The molecule’s effects on TRPV1, a protein linked to sensing pain, heat, and irritation, were evaluated using human keratinocyte cells. COS-diDA reduced TRPV1 protein levels significantly and lowered inflammatory cytokines IL-1α, IL-6, and IL-8.

Key findings also show COS-diDA is non-toxic to skin cells, with optimal benefits at 0.8 μg/mL concentration. It adheres well to cells due to dopamine’s properties, potentially enhancing skincare product longevity and effectiveness. The structure formed by COS-diDA appears ideal for a protective skin layer.

This research marks a step towards COS-diDA’s use in skincare, particularly for sensitive skin affected by environmental and lifestyle factors. It offers a natural alternative to synthetic anti-inflammatory agents, suitable for brands focusing on sustainable products. However, clinical trials are needed to confirm safety and effectiveness on human skin.

Future research plans include exploring COS-diDA in real-life skin models, interactions with other skincare ingredients, and scalable manufacturing processes. The study, led by Yue Su and published in “Cosmetics,” provides a promising foundation for COS-diDA’s potential in skincare and cosmeceuticals.